Research use only. Results apply the rules proposed in the guidelines paper to the IPD-IMGT/HLA Database; any clinical application requires independent validation according to local regulations.
Full table: one row per allele

44,389 alleles, one row each, with the WHO and HATS fields behind each value.

CSV (5.7 MB) Excel (2.6 MB) PDF (5.5 MB)
Two-field table: one row per two-field group

25,342 two-field groups (null and Q alleles left out), with whether all alleles of the group agree.

CSV (3.3 MB) Excel (0.9 MB) PDF (3.5 MB)
Versions recorded in every file

CSV files start with lines beginning with #; read them with readr::read_csv(file, comment = "#"). Opened directly in Excel, a CSV turns OPTN values such as 02:01 into times; use the Excel download instead. In R, read the Excel file with readxl::read_excel(file, col_types = "text"). Excel files have an About sheet, and PDFs list the versions on the first page.

What this is

A reference implementation of the rules for assigning serologic equivalents to HLA alleles under the 2026 HLA nomenclature, as proposed in a guidelines paper from the American Society for Histocompatibility and Immunogenetics (ASHI) Professional Standards Division (submitted for publication), applied to every public allele in the IPD-IMGT/HLA Database at the loci A, B, C, DRB1, DRB3, DRB4, DRB5, DQA1, DQB1, DPA1 and DPB1.

The rules, in order
  1. Null allele: no serologic equivalent.
  2. WHO-assigned split, if there is one.
  3. Otherwise the HATS-assigned split, but only if its broad is the same as any WHO-assigned broad; a HATS split under a different broad is a discordant assignment, and the WHO assignment is kept.
  4. Otherwise the WHO-assigned broad, or the HATS-assigned broad if WHO has none.
  5. Alleles displayed with only an associated antigen get its parent antigen.
  6. Otherwise unresolved: laboratory director review; report the allele name.

The associated-antigen level reports the WHO associated antigen, or the HATS associated antigen when its qualifier is FULL and it agrees with WHO; otherwise it repeats the split level. OPTN values are the values OPTN Policy 4.11 accepts for each antigen at its locus.

HATS assignments are used as the IPD-IMGT/HLA Database displays them, that is, only with the FULL or SEROTYPE qualifier. Alleles that HATS classes as incomplete or in silico therefore have no HATS value here.

Sources
  • WHO and HATS assignments: the IPD-IMGT/HLA Database (European Bioinformatics Institute), release 3.66.0, https://www.ebi.ac.uk/ipd/imgt/hla/, through its REST API, as displayed on the allele reports.
  • Broad, split and associated-antigen relationships: WMDA rel_ser_ser.txt of the same release, read with HLAtools (S. J. Mack).
  • Allele-name handling: immunogenetr.
  • OPTN values: OPTN Policy 4.11, Tables 4-5 to 4-15 (policies effective October 1, 2026).

Research use only; any clinical application requires independent validation according to local regulations.

Hosted by the Perelman School of Medicine at the University of Pennsylvania. Algorithm version 0.1.0, commit 56876b3; tables built 2026-11-09.